硫普罗宁致全身肌肉疼痛2例

Two cases of tiopronin induced muscle pain

硫普罗宁在临床上广泛用于各种肝脏疾病的治疗,可降低升高的肝酶及改善肝功,常见的不良反应为皮疹、皮肤瘙痒、面色潮红等过敏反应;过敏性休克;药物热;呼吸困难;颌下腺肿大、腮腺肿大、恶心、呕吐、腹痛和腹泻等。致肌肉疼痛未见报道,本文将报道我科室硫普罗宁致全身肌肉疼痛病例2例,并分析相关临床病理特点及治疗预后,可供临床安全用药参考。

Tiopronin in clinical widely used in treatment of various liver diseases can be decreased with the increase of liver enzymes and improving the function of liver, common adverse reactions to skin rash, itching, flushing and other allergic reactions; anaphylactic shock; drug fever; difficulty breathing; swelling of submaxillary gland, parotid swelling, nausea, vomiting,abdominal pain and diarrhea. Muscle pain caused have never reported. This paper reports our department tiopronin Ning induced systemic muscle pain cases in 2 cases, and analysis of clinical and pathological characteristics, treatment and prognosis of the disease, which can be used for reference in clinical medication safety.