基质金属蛋白酶及其抑制剂在心血管疾病中的研究进展

Progress of Matrix metalloproteinases and their Inhibitors in Cardiovascular disease

基质金属蛋白酶(MMPs)及其抑制剂(TIMPs)在心肌细胞的损伤、心肌重构中有着重要的影响,因其发生发展过程复杂,主要机理目前还不完全明确,但众多研究表明,MMPs和TIMPs的动态平衡在心肌损伤中起着至关重要的作用,甚至可以为心肌梗死的早期检测和及早治疗而开发出一种新型的检测试剂,可以有效提高心血管疾病的早期诊断,对后续的治疗起到准确、科学的指导作用。下面就基质金属蛋白酶及其抑制剂在心血管疾病方面近几年的研究结果进行综述。

Matrix metalloproteinases and their inhibitors have a significant impact on Myocardial injury and remodeling in cardiac myocytes.Because of the complex development process,the main mechanism is unentire clear. A few studies have shown that dynamic equilibrium between MMPs and TIMPs played a vital role in myocardial injury, and it could develop a new detection reagents for early detection and early treatment of myocardial infarction. It not only can effectively improve the early diagnosis of cardiovascular disease, but also plays accurate scientific guidance subsequent treatment. Now it will be summarized that the progress of Matrix metalloproteinases and their inhibitors in Cardiovascular disease in recent years.