胎儿胸腔积液的产前诊治

Study on Prenatal Diagnosis and Therapy of Fetal Pleural Effusion

目的 分析胎儿胸腔积液的病因、诊断方法及治疗。方法 对 7例患有胸腔积液的胎儿抽取脐静脉血行染色体核型、TORCH、血红蛋白电泳、血型等检查 ;其中 3例胎儿行胸腔穿刺术 ,抽取胸水行细胞检查、胸水生化及TORCH、衣原体、支原体及细菌培养。结果 6例胎儿确定病因 ,1例胎儿行胸腔穿刺术后分娩一健康活婴 ,1例胎儿宫内输血后死亡 ,5例胎儿引产。结论 胎儿胸腔积液可通过侵入性产前诊断以明确病因 ,对染色体核型及结构正常的胎儿可行相应的宫内治疗。

Objective To study the etiology,diagnosis and therapy of fetal pleural effusion.Methods Cordocenteses were performed in 7 fetuses with pleural effusion and then chromosomal karyotypes,TORCH,hemoglobin electrophoresis and blood groups were analyzed.Among all the 7 fetuses,thoracenteses were conducted in 3 fetuses,and cytoscoph,biochemical analyses,TORCH,culture of chlamydia,mycoplasma and bacteria were performed in the pleural fluids.Results The etiology of 6 cases was comfirmed.One healthy infant was born after thoracentesis.Another one fetus was dead after intrauterine transfusion.5 fetuses were induced labor.Conclusion Invasive Prenatal Diagnosis was necessary in fetuses with pleural effusion.Intrauterine therapy could be done in those fetuses with normal chromosomal karyotypes and structure.