广西梧州市鼻咽癌现场10年的前瞻性研究

PROSPECTIVE STUDIES OF NASOPHARYNGEAL CARCINOMA FOR 10 YEARS IN WUZHOU CITY,GUANGXI

1980年我们在梧州市对20726人进行Epstein-Barr病毒(EBV)壳抗原的IgA类(IgA/VCA)抗体的血清学普查,发现抗体阳性者1136人。当时进行临床和组织学检查共发现18例鼻咽癌病人。经10年追踪观察又发现29例病人,其中1、2期病人25例,早期诊断率达86.2％。血清学普查后在抗体阳性者中逐年追踪,甚至在第10年仍可发现鼻咽癌病人。未追踪的抗体阳性者中发生6例,共计53例,占全部57例(包括抗体阴性者4列)鼻咽癌的93％。因此,根据血清学指标可以在5～10年前预测鼻咽癌发生的可能性,抗体阳性者只要能定期追踪检查就可以在早期发现鼻咽癌。这些结果进一步说明EB病毒与鼻咽癌的发生密切相关。

A serological mass survey of NPC was carried out in Wuzhou city, Guangxi. 1,136 out of 20,726 persons of age over 40 had Epstein-Barr viral IgA/VCA antibody. Among them 18 patients were diagnosed just after serological screening.The IgA/VCA positive-persons were followed up yearly for 10 years. The early detection rate for NPC increased from 25.8% to 87.2%. NPC could be detected up to 10th year. Therefore, NPC can be predicted 5-10 years before diagnosis of NPC was made.Altogether 57 NPC patient ( 93% ) were detected from the IgA/VCA antibody positive group, while only 4( 7% )from the antibody negative group. The NPC detection rate of NPC in these two groups was 4665.5 /100,000 and 20.4/100,000 respectively. All these data indicate that Eps tein-Barr virus plays an important role in the development of NPC.