广西地区壮、汉族人群apoCⅢ基因多态性研究

A study of apoCⅢ gene polymorphism between the Zhuangzu people and the Hanzu people in Guangxi

目的 :研究广西壮、汉族人群载脂蛋白 C (apoc )基因多态性 ,以获得广西壮、汉族人群 apoc 基因频率分布资料。方法 :以 apoc 基因为候选基因 ,应用聚合酶链反应 -限制性片段长度多态性 (PCR- RFL P)方法检测 114例汉族人和 10 7例壮族人的 apoc 基因型。结果 :广西壮、汉族人群 S1 和 S2 等位基因的频率分别为 0 .70 6比 0 .772和 0 .2 94比0 .2 2 8(P >0 .0 5 )。结论 :广西壮、汉族人群 apoc 基因多态性无显著性差别。

Objective:To study apolipoprotein CⅢ(apoCⅢ)between the Zhuangzu people and the Hanzu people in Guangxi Methods:Using apocⅢ gene as a candidate tene,the apocⅢ genotypes were determined in the 114 Zhuangzu people and the 107 Hanzu people by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) Results:The frequencies of S 1 and S 2 alleles were 0 706 vs 0 772 and 0 294 vs 0 228 in the Zhuangzu people and the Hanzu people respectively (P>0 05) Conclusion:The apocⅢ gene polymorphism was not significant difference between the Zhuangzu people and the Hanzu people in Guangxi