新乐市格林-巴利综合征长期流行病学趋势兼与欧美趋势比较

Epidemiological trends of Guillain-Barre syndrome in Xinle city and comparison with those in Europe and America

目的 分析格林 -巴利综合征 (GBS)在河北省石家庄地区新乐市的流行病学趋势并比较与欧美的异同。方法 对 1975～ 1995年河北省新乐市 GBS发病率、季节及年龄分布进行研究。结果 这一地区的年均发病率为 0 .5 8/10万 ,2 1年间的长期发病率有显著的波动 ,出现了两个流行高峰和一个流行周期 ,发病有明显的夏秋季的季节性和周期性地区丛集现象 ,具有青少年高发的特点。结论 这些不同于欧美 GBS的流行病学特征提示这一地区的 GBS可能主要由一种传染性因子所致。 GBS可能是一些传染因子在个别被感染者中产生的一个“副产品”

Objective To analyze the epidemiologic trends of Guillain Barre Syndrome(GBS) in Xinle city in China and to compare them with those in Europe and America. Methods The incidences from 1975 to 1995 in Xinle city were studied. Results The mean annual incidence was 0.58 per 100 000 population in this area. Incidence significantly fluctuated with time. There were two epidemic peaks and one epidemic cycle. The clear seasonal clusterings occurred in summer and autumn. There were periodic geographic clusterings. The higher incidence was observed in children and young adults. Conclusion These epidemiologic features being different from those in Europe and America suggests that GBS in this area may be mainly caused by one infectious agent. GBS may be a 'by product' produced by certain infectious agent in some involved individuals.