蟾酥β-环糊精包合物的制备工艺

Study on the Preparation of Venenum Bufonis β-Cyclodextrin Inclusion Complexes

目的 :研究蟾酥 β 环糊精包合物的制备工艺。 方法 :采用均匀设计法筛选优化出最佳制备条件 ,在此条件下分别采用 5种不同的包合方法制备蟾酥 β 环糊精包合物。 结果 :采用球磨法制备蟾酥 β 环糊精包合物 ,优于其他几种制备方法 ,其蟾毒配基类化合物的包合率达 85 .4 2 %。结论 :在本实验考察范围内 ,球磨法为最佳制备方法。

Objective:To study the preparation of Venenum Bufonisβ-cyclodextrin inclusion complexes.Method: An optimal condition was established by the uniform design. Under the optimal conditions the Venenum Bufonis β-cyclodextrin inclusion complexes were prepared with 5 different methods. Result:The ball grinding method was superior to other four methods. The bufadienolide inclusion rate of Venenum Bufonis β-cyclodextrin prepared with ball grinding method was 85.42%. Conclusion: Ball grinding method is the best method for the preparation of Venenum Bufonis β-cyclodextrin inclusion complexes.