摘要
目的 :探讨慢性肝病患者血清 TGF- α和 TGF- β1 的变化及其意义。方法 :用放免法和双抗体夹心 EL ISA法分别测定10 4例慢性肝病患者血清的 TGF- α和 TGF- β1 。结果 :慢性肝炎、肝硬化及原发性肝癌患者血清的 TGF- α和 TGF- β1 含量均显著升高 ;原发性肝癌患者的 TGF- α明显高于慢性肝炎及肝硬化患者 ;血清的 TGF- α和 TGF- β1 在各组患者中呈显著的正相关。结论 :检测血清 TGF- α和 TGF- β1 ,对于慢性肝炎。
Objective:To investigate the changes and clinical significances of serum transforming growth facfor α(TGF α) and transforming growth factor β 1 (TGF β 1) in patients with chronic liver disease Methods: Serum TGF α was measured by RIA and TGF β 1 was measured by ELISA in 104 cases with chronic liver diseases Results: The levels of TGF α and TGF β 1 were significantly higher in patients with chronic hepatitis (CH), liver cirrhosis (LC) and primary hepatic cancer (PHC) than those in control group The level of TGF α in PHC is obviously higher than CH and LC There was a close positive correlation between TGF αand TGF β 1 in a various of chronic liver diseases Conclusion: It is suggested that the detection of srum TGF αand TGF β 1 is valuable in judging patients condition and progrosis of CH, LC and diagnosis PHC
出处
《广西医科大学学报》
CAS
2002年第5期626-627,共2页
Journal of Guangxi Medical University
基金
广西科技厅科学研究与技术开发计划项目的资助 (桂科基 0 14 3 0 5 9)
