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阻塞性睡眠呼吸暂停综合征和重叠综合征的肺功能变化及其临床意义 被引量:14

CHANGES OF LUNG FUNCTION AND CLINIC SIGNIFICANCE IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA SYNDROME AND OVERLAP SYNDROME
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摘要 目的 :探讨阻塞性睡眠呼吸暂停综合征 (OSAS)以及 OSAS合并慢性阻塞性肺病 (COPD) (以下称重叠综合征 )患者的肺功能变化及其与睡眠呼吸紊乱的关系。方法 :观察对象 14 1例 ,其中 OSAS组 6 2例 ,重叠综合征组 5 2例 ,正常对照组 2 7例 ,14 1例均行肺功能测定 ,并比较 3组的呼吸暂停低通气指数 (AHI)和肺功能指标、夜间睡眠最低血氧饱和度 (L Sa O2 )的变化和关系。结果 :OSAS组的用力肺活量 (FVC)、最大通气量 (MVV)明显低于正常对照组 (P均 <0 .0 1) ,重叠综合征组的 1s用力呼气容积 (FEV1)、FVC、MVV、最大呼气中段流量 (MMEF)均明显低于 OSAS组和正常对照组 (P均 <0 .0 1) ;两组患者的L Sa O2 均明显低于正常对照组 (P均 <0 .0 1)。 OSAS组 AHI与 FVC、MVV、功能残气量 (FRC)呈负相关 ,其 L Sa O2 与 FVC、MVV、FRC呈正相关 ;重叠综合征组 AHI与 FEV1、FVC、MVV、MMEF呈负相关 ,其 L Sa O2 与 FEV1、MVV、MMEF呈正相关 ,两组的 L Sa O2 与 AHI均呈负相关。结论 :睡眠呼吸暂停与肺功能变化及夜间低氧血症有关 ,OSAS患者睡眠呼吸暂停的严重程度及睡眠血氧饱和度下降与肺容量减少有关 ,重叠综合征患者因肺功能减低、气道阻力增高而加重睡眠呼吸紊乱和夜间低氧血症。 Objective:To study relationship of lung function and sleep breath disorder in patients with obstructive sleep apnea syndrome (OSAS) and overlap syndrome sleep apnea to combine chronic obstructive pulmonary disease (COPD) Methods:One hundred forty one subjects were detected by polysomnography and lung function, then they were divided to 3 groups according to apnea hypopnea index(AHI) and lung function 62 patients were included in Group OSAS, 52 patients were in Group overlap syndrome, normal 27 subjects were in Group control Lung function included forced expiratory volume in one second (FEV1), forced vital capacity (FVC), maximal voluntary ventilation (MVV), maximal midexpiratory flow curve (MMEF) and functional residual capacity (FRC) Change of AHI, lung function and the lowest oxygen saturation (LSaO 2) at night were compared in three groups Results:FVC,MVV in Group OSAS were significantly lower than those in Group control(P<0 01), FEV1?FVC?MVV?MMEF in Group overlap syndrome were significantly lower than those in Group OSAS and in Group control(P<0 01), LSaO 2 in Group OSAS and in Group overlap syndrome were significantly lower than that in Group control(P<0 01) AHI was inversely related to the FVC,MVV,FRC,and the LSaO 2 was positively related to the FVC,MVV,FRC in Group OSAS;AHI was inversely related to the FEV1?FVC?MVV?MMEF, and the LSaO 2 was positively related to the FEV1?FVC?MVV?MMEF in Group overlap syndrome, LSaO 2 in Group OSAS and in Group overlap syndrome were inversely related to the AHI Conclusions:Sleep apnea and hypoxemia at night is correlated with changes of lung function, severity degree of sleep apnea and oxygen desaturation are correlated with decrease of lung volume in patients with OSAS, reduction of lung function and increase of airway resistance could aggravate sleep induced respiratory abnormalities and hypoxemia at night in patients with overlap syndrome
出处 《广西医科大学学报》 CAS 2002年第5期634-636,共3页 Journal of Guangxi Medical University
关键词 阻塞性睡眠呼吸暂停综合征 重叠综合征 肺功能 慢性阻塞性肺疾病 OSAS COPD obstructive sleep apnea syndrome overlap syndrome lung function
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