从新西兰兔高侧壁心肌坏死前后病理性Q波的变迁看Q波的形成

Pathological Q-wave generation in light of the Q wave alteration resulting from myocardial infarction in the left ventricular lateral wall of New Zealand rabbits

目的从新西兰兔心肌坏死动物模型复制前后Q波在体表位置的变迁探讨病理性Q波的形成原因。方法30只新西兰兔采用Wilson导联记录其胸背部预定点的心电图,与经定量化学损伤法复制的高侧壁心肌坏死动物模型相同体表测试点记录的心电图进行比较,统计相关位点出现病理性Q波的例数。结果在坏死区域正对的体表部位出现了病理性Q波,而对应区域的病理性Q波消失。经配对计数资料的χ2检验, 有显著性差异(P<0.05)。结论病理性Q波可能是负性的心室腔电位通过该坏死“窗口”传到体表形成的。

Objective To explore the mechanism of pathological Q-wave generation in light of Q-wave alteration recorded on body surface resulting from the myocardial infarction in left ventricular lateral wall of New Zealand rabbits. Method Electrocardiogram (ECG) was recorded with Wilson lead system at the surface points of chest and back in 30 normal rabbits. The myocardiac infarction models were prepared with quantitative chemical damaging method, and the ECG was recorded at the same points. Through comparison with the recorded ECG in normal animals, cases with pathological Q-wave at the recorded sites were identified and counted. Result Pathological Q waves appeared at the point toward the infarction region, which was not observed in the area of right ventricular lateral wall opposite to the infarction region, showing significant difference (P<0.05). Conclusion Negative potential transmitting from the ventricular chamber to the body surface through the window of infarction region may be involved in the generation of pathological Q waves.