哌嗪取代二氢吡啶新衍生物的合成及其钙拮抗活性研究

Study on Synthesis and Ca^(2+) Antagonizing Activity of Piperazine Substituted New Dihydropyridine Derivatives

设计并合成了 5个哌嗪取代二氢吡啶新衍生物 ,并用 45Ca跨膜内流动测定方法研究了目标物对大鼠主动脉电压依赖性钙离子通道 (PDC) Ca2 +内流的影响。结果显示 5个化合物对 PDC的阻滞作用强于阳性对照物硝苯吡啶 ,表明它们均具有较强的钙拮抗活性 。

Five new piperazine substituted dihydropyridine derivatives were designed and synthesized. Their inhibitive effects on potential dependent calcium ion channels (PDC) in rat aorta were determined by 45 Ca transmembrane influx technique. The results showed that their inhibitive effects on PDC were better than that of nifedipine, and they possessed Ca 2+ antagonizing activity.