摘要
建立了盐酸多巴酚丁胺葡萄糖注射液以及葡萄糖降解产物 5 -羟甲基糠醛含量的 HPL C测定法。用 DiamonsilC1 8色谱柱 ,以辛烷磺酸钠缓冲液 (p H 2 .5 ) -乙腈 -甲醇 (5 8∶ 2 8∶ 14)为流动相 ,检测波长为 2 78nm。盐酸多巴酚丁胺和 5 -羟甲基糠醛分别在 5 0~ 2 0 0 μg/ ml和 0 .2 5~ 3.5 μg/ ml范围内线性关系良好。盐酸多巴酚丁胺的方法平均回收率为 10 0 .0 % ,RSD为 1.0 %。日内和日间精密度小于 1.6 %。
A HPLC method for the determination of dobutamine hydrochloride glucose injection and the related substance of glucose——5 hydroxymethyl furfuraldehyde was established. A Diamonsil C 18 column was used, with the mobile phase of sodium 1 octanesulfonate buffer solution(pH2.5) acetonitrile methanol(58∶28∶14). The detection wavelength was 278 nm. The calibration curves of dobutamine hydrochloride and 5 hydroxymethyl furfuraldehyde were linear in range of 50~200 μg/ml and 0.25~3.5 μg/ml, respectively. The average recovery of dobutamine hydrochloride was 100.0%( RSD 1.0%) and the RSD of intra and inter day was less than 1.6%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2002年第10期497-498,共2页
Chinese Journal of Pharmaceuticals