免疫球蛋白在胆囊胆固醇结石形成中的作用研究

Studies on the Effect Between Inununoglobulin and Cholesterol Gallstone Fonnation

目的:探讨胆囊胆汁和胆囊组织中免疫球蛋白在胆囊胆固醇结石形成中的作用。方法:采用放射免疫分析(RIA)方法分别测定了56例胆囊胆固醇结石及24例非胆石对照患者胆囊组织和胆囊胆汁中sIgA、IgG、IgM、IgE的含量。结果:胆囊胆固醇结石组胆囊组织和胆囊胆汁中sIgA、IgG、IgM、IgE均与对照组有显著性差异(P<0.01或P<0.05),并且胆囊胆固醇结石组胆囊组织中sIgA、IgM、IgE与胆囊胆汁中的sIgA、IgM、IgE成显著正相关关系。多发结石组胆囊胆汁中IgG与单发结石组有显著性差异(P<0.05),而其sIgA、IgM、IgE及胆囊组织中sIgA、IgG、IgM、IgE与单发结石组虽无显著性差异,但均有升高。结论:本实验结果提示:胆囊组织及胆囊胆汁中免疫球蛋白sIgA、IgG、IgM、IgE与胆囊胆固醇结石的形成密切相关,并在胆囊胆固醇结石的形成过程中起着重要作用,为胆囊胆固醇结石形成过程中的重要促成核因子。

Purpose: To investigate the role of immunoglobulin of gallbladder organization and gallbladder bile during cholesterol gallstone formation. Methods: Patients were divided into two groups: cholesterol gallstone patients group (56 randomly selected patients) and control group (24 randomly selected no cholelithiasis patients). Immunoglobulin IgA, IgG, IgM and IgE in gallbladder tissue and gallbladder bile were measured with radioimrnunoassay. Results: In the cholesterol gallstone group, slgA, IgG, IgM and IgE in gallbladder tissue and gallbladder bile were significantly different respectively, compared with control group (P<0.01orP<0.05). In cholesterol gallstone group, slgA, IgG, IgM and IgE in gallbladder tissue and in gallbladder bile have significantly positive correlativity. Conclusion: These results indicate that immunoglobulin slgA, IgG, IgM and IgE in gallbladder tissue and gallbladder bile may take an important role in the formation cholesterol gallstone, and they were important nucleating factors.