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719例肝硬化病因分析 被引量:7

Etiological Analysis of Liver Cirrhosis of 719 Cases
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摘要 目的:探讨近年我国肝硬化病因的特点及其变化。方法:回顾性分析北京协和医院1994年1月至2002年2月719例肝硬化住院病人的病因。结果:乙型病毒性肝炎后肝硬化413例(57.44%),丙型病毒性肝炎后肝硬化40例(5.56%),酒精性肝硬化50例(6.96%),自身免疫病引起者48例(6.68%),另有57例(7.93%)同时存在乙型病毒性肝炎和酒精因素。按时期分为前4年和后4年分别分析。显示酒精性肝硬化由4%增加到9.76%,自身免疫性肝硬化由4%增加到9.21%,均呈随时间增加趋势。本组病人中99例(13.77%)合并肝癌,其中97例与病毒性肝炎相关。结论:病毒性肝炎(主要为乙肝)仍是我国肝硬化的最主要病因,而洒精性和自身免疫性肝硬化的发病率呈上升趋势,应引起足够的重视。 Purpose: To analyze the causes of liver cirrhosis and their changes in recent years in Peking Union Medical College Hospital. Methods: 719 inpatients with liver cirrhosis (Jan 1994~Feb 2002) were investigated retrospectively. Results: 413(57. 44% ) cases were caused by the infection of hepatitis B virus, 40(5.56%) by hepatitis C virus. Alcohol was accounted for 50 cases(6. 96%). 48 (6.68%) cases were caused by autoimmune diseases. Two factors (hepatitis B virus and alcohol) existed in 57(7. 93%) patients. The patients were divided into two groups of before-Jan 1998 and after-Jan 1998, and the above eti-ological factors were further analyzed. It was found that the incidence of alcoholic cirrhosis increased from 4% in before-Jan 1998 group to 9.76% in after-Jan 1998 group. Also, the incidence of cirrhosis caused by autoimmune diseases increased from 4% to 9. 21% . 99(13. 77% ) cases of hepatic carcinoma were found from all 719 patients and 97 out of 99 cases were related to hepatitis viruses. Conclusion: It is suggested that hepatitis B virus is still the major cause of liver cirrhosis in China. Cirrhosis caused by alcohol and autoimmune diseases reveals a tendency of increase, to which more attention should be paid.
作者 孙钢 陶红军
机构地区 中国医学科学院
出处 《临床消化病杂志》 2002年第5期207-209,共3页 Chinese Journal of Clinical Gastroenterology
关键词 肝硬化 酒精 病毒性肝炎 自身免疫病 病因 Cirrhosis Alcohol Viral hepatitis Autoimmune disease Etiology
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  • 1张道明,中华消化杂志,1993年,13卷,132页

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