丙基硫氧嘧啶对冷环境中大鼠体温的影响

Effects of propylthiouracil on body temperature in rats during cold exposure

目的 :研究冷暴露对大鼠体温调节功能的影响。方法 :给大鼠服用抗甲状腺素药物丙基硫氧嘧啶(PTU)复制甲状腺功能低下模型。用数字体温计测量大鼠的结肠温度 ,放射免疫方法测量血浆中的T3 和T4浓度。在连续给PTU两周后 ,观察大鼠暴露到冷环境中时体温的变化。结果 :给大鼠PTU两周后 ,血浆中T3 和T4浓度显著低于对照组 (P <0 .0 1) ,同时体温也明显降低 (P <0 .0 1) ;但将大鼠置于 6℃冷环境中时 ,体温的升高反应与对照组比较无明显差异。结论 :甲状腺功能低下的大鼠短时间暴露于冷环境中 ,仍具有足够的生热反应。

AIM: To investigate the effect of cold exposure on the thermoregulatory function in hypothyroid rats. METHODS: Hypothyroid model was established by administration of antithyroid drug propylthiouracil(PTU) in rats. Colonic temperature was measured using digital thermometer. Plasma T_3 and T_4 concentrations were determined by radioimmunoassay. The effect of cold exposure on body temperature was observed after 2 weeks of PTU treatment. RESULTS: Plasma T_3 and T_4 concentrations were reduced markedly 2 weeks after PTU treatment, and colonic temperature was also decreased markedly; Hyperthermic response was not different between PTU group and control group during cold exposure. CONCLUSION: This study suggests that PTU-induced hypothyroid rat possesses a robust thermogenic response to short bouts of cold exposure.