摘要
目的 探讨血管紧张素转换酶抑制 (ACEI)对糖尿病肾病 (DN)的影响 ,以寻求DN有效治疗方法。方法 应用福辛普利治疗了 4 6例早期DN患者 ,并与硝苯地平治疗组进行比较。结果 福辛普利治疗后 ,尿微量白蛋白排泄率 (UAE)明显降低 (P <0 .0 1) ,内生肌酐清除率 (Ccr)无明显变化 (P>0 .0 5 ) ;而硝苯地平组UAE明显升高 (P <0 .0 1) ,Ccr明显降低 (P <0 .0 1)。结论 ACEI 福辛普利能降低DN尿蛋白 ,减轻肾损害 。
Objective To study the effect of angiotensin converting enzyme inhibitor(ACEI),on diabetic nephropathy.Method 46 incipient diabetic nephropathy patients was treated with fosinopril,and compared with nifedipin .Result That urinary albumin excretion rate(UAE) in fosinopril group were significant.Geatinine clearance rate(Ccr) didn't change significantly than before(P>0.05).But in nifedipin group,the UAE increased significantly than before(P<0.01),and Ccr decreased significantly than before(P<0.01).Conclusion Fosinopril may have effective on the decrease of albuminuria and protection of renal function.
出处
《潍坊医学院学报》
2002年第3期183-184,共2页
Acta Academiae Medicinae Weifang
