摘要
目的 观察雾化烧伤灵治疗烧伤的药理学作用并探讨其作用机制。方法 制作豚鼠浅Ⅱ度、深Ⅱ度烧伤模型及Ⅲ度烧伤感染模型 ,观察雾化烧伤灵组 (实验组 )、湿润烧伤膏组 (药物对照组 )及空白对照组 (溶剂组 )烧伤创面结痂面积、脱痂时间和愈合时间的变化。结果 与空白对照组比较 ,雾化烧伤灵组可明显减少创面渗出、缩小结痂面积、缩短脱痂时间及愈合时间 (P <0 .0 1) ,且其作用明显优于湿润烧伤膏组 (P <0 .0 5 ) ,并可抑制烧伤创面绿脓杆菌的感染。结论 雾化烧伤灵具有明显的促进烧伤创面愈合及创面抗感染作用 。
Objective To observe the pharmacology action of Shaoshangling Spray(SSLS) on treatment to burn and research it's effect mechanism.Method Make guineapig models of low and deep second degree burn and the third degree burn infection,observe scab area,decrustation and healing time changes of burn surface in treatment(SSLS) group,drug control (Moist Burn Ointment,MBO )group and no drug control(Solvent S.) group.Result Comparing with no drug control group,treatment group can apparently decrease burn surface exudation,scab area,decrustation and healing time(P<0.01),and the last two action were apparently better than MBO group(P<0.05),furthermore the SSLS group can inhibit infection of green pus bacillus to burn surface.Conclusion SSLS have obvious effects on promoting burn surface healing and anti infection.It is a perfect external drug to burn.
出处
《潍坊医学院学报》
2002年第3期191-192,共2页
Acta Academiae Medicinae Weifang
基金
潍坊市科委资助课题 (课题号 :)
关键词
烧伤
雾化烧伤灵
药效学
豚鼠
Burn
Shaoshangling spray
Pharmacodynamics
Guineapig