老年高血压患者颈动脉硬化超声与内皮功能检查的价值研究

The value study of carotid artery atherosclerotic plaque and endothelial function in elderly hypertensive patients

目的 :探讨老年高血压病患者内皮功能与颈动脉粥样硬化之间的关系。方法 :选择 15 0名老年高血压病患者为研究对象 ,分别测定血一氧化氮合成酶 (NOS)、内皮素 (ET)水平 ,同时行颈动脉超声检查 ,检测颈动脉血管粥样硬化斑块大小、内回声并进行斑块分类。结果 :NOS降低或ET水平增高组颈动脉斑块积分、孤立性斑块个数明显高于NOS和ET水平正常组 (P <0 .0 5 ) ,且多为不稳定斑块。结论 :老年高血压病患者均有不同程度的内皮功能障碍 ,内皮功能受损导致一氧化氮 (NO)、ET分泌失调促使动脉粥样硬化的发生与发展 ,颈动脉超声检查简便易行 。

Objective:To explore the relationship between endothelial function and carotid atherosclerotic plaque in elderly hypertensive patients.Methods:Nitric oxide synthase(NOS), endothelial(ET)and carotid artery ultrasonography were perfomed in the studied 150 elderly hypertensive patients .The carotid artery plaques were measured and classed,the scores of carotid artery plaques were calculated.Results:The scores of carotid artery plaques and number of independent plaques were significantly more in NOS decrease group or ET increase group than in normal NOS and ET group(P<0.05) , and most of these plaques were unstable ones.Conclusion:The elderly hypertensive patients had endothelial dysfunction in mvarying degrees,endothelial dysfunction leading to abnormal Nitric oxide (NO ),ET secrete impel the emergence,developments of atherosclerosis.Ultrasonography is simple and easy to check carotid artery, can be regarded as a window which watch the whole body atheroscl erosis.