口服VitC对小鼠急性肺泡炎的致损伤作用

Traumatogenic Effect of Oral Administration of Vitamin C on Acute Alveolitis in Mice

目的 以小鼠急性肺泡炎动物模型为研究对象,观察口服VitC、VitE对小鼠免疫复合物性肺损伤的作用。方法 以牛血清白蛋白致敏昆明小鼠建立急性肺泡炎动物模型,观察单独口服VitC、VitE及同时口服VitC、VitE对小鼠急性肺泡炎发生率的影响。结果 急性肺泡炎发生率VitE组明显低于阳性对照组,而VitC组和VitE+vitC组则与阳性对照组一致,均为100％,漏出性出血的发生率明显高于阳性对照组。结论VitE可一定程度地抑制小鼠急性肺泡炎的发生,而VitC不仅不能抑制,相反可加重小鼠急性肺泡炎肺损伤的程度。

Objective To test the effect of vitamin C and vitamin E on the pulmonary injury in experimental pulmonary alveolitis. Methods Mouse model of acute pulmonary alveolitis developed with BSA sensitization and antigen inhalation was used for tests of the effect of oral administration of vitamin E(VE group), vitamin C (VC group)andr both vitamin E and vitamin C (VEC group ) on the incidence of developing acute pulmonary alveolitis. Results The VE group's incidence of acute pulmonary alveolotis is dropped from 100% of the untreated group down to 43%, but the VC group and VEC group' s incidence of acute pulmonary alveolitis is 100% as the untreated group , and it' s incidence of transudatory hemorrhage is remarkably increased from 22.2% of the untreated group to 100%. Conclusions The induction of pulmonary alveolitis can be inhibited by oral administration of vitamin E, otherwise, it can be improved by oral administration of vitamin C.