胃粘膜癌变过程中Fas、FasL的表达及意义

The expression and significance of Fas, Fas ligand in carcinogenesis of gastric mucosa

目的:通过检测胃粘膜癌变过程中凋亡相关蛋白、的表达,探讨其在胃癌发生发展中的作用。FasFasL方法:采用免疫组化法检测例慢性浅表性胃炎()、例慢性萎缩性胃炎伴肠化生()、例异型增生()和例SP41CSG19CAGIM22Dys37胃癌()。GC结果:在、、和组中的阳性表达率依次下降,的阳性表达率则逐渐升高;、FasCSGCAGIMDysGCFasLFasFasL在高中分化组的阳性表达率均显著高于低分化组。GCGC结论:、的阳性表达率在胃癌发生过程中呈现不同的变化趋FasFasL势,提示由诱导的胃粘膜细胞凋亡异常与胃癌形成可能有密切关系。在胃癌患者,与癌细胞分化有关的、表Fas/FasLFasFasL达的一致性有助于判断肿瘤的恶性程度和预后。

Objective: To investigate the expression and significance of Fas, Fas ligand in carcinogenesis of gastric mucosa. Methods: SP immunohistochemistry. Results: The expression rate of Fas in chronic superficial gastritis group was significantly higher than that of dysplasia and gastric cancer groups (P<0.05). The expression rate of Fas ligand in chronic superficial gastritis group was significantly lower than that of other groups ( P<0.05). In the patients with gastric cancer, the expression rates of Fas and Fas ligand were correlated with the degree of differentiation. Conclusion: The abnormal expression of Fas and Fas ligand in carcinogenesis of gastric mucosa may be involved in the pathogenesis and differentiation of gastric cancer.