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内吗啡肽-1对神经源性疼痛镇痛作用的实验研究 被引量：1

The analgesic effect of endomorphin-1 on neuropathic pain
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摘要 目的 :观察内吗啡肽 1(endomorphin 1,EM 1)对神经源性疼痛动物的镇痛作用。方法 :用大鼠单侧坐骨神经部分结扎制成神经源性疼痛动物模型 ,采用钾离子透入法和辐射热 缩腿法两种测痛方法 ,观察腹腔注射EM 1(5 0 μg/kg)的作用。 结果 :EM 1对神经源性疼痛急性期和慢性期的痛阈均有提高作用 ,并且EM 1的作用可被纳络酮逆转。结论 :EM 1对神经源性疼痛急性期和慢性期的痛觉过敏均有镇痛作用。 Objective:To observe the analgesic effect of endomorphine 1(EM 1) on neuropathic pain model.Methods:The experiment was performed in rats which right sciatic nerve was partly crushed by K\++ iontophoresis and leg withdrawal to radiant heat to observe the analgesic effect of intraperitoneal injection(IP) of EM 1(50 μg/kg).Results:EM 1 could decrease the hyperalgesia in neuropathic pain model.The analgesic effect of EM 1 could be reversed by naloxone.Conclusions:EM 1 has analgesic effect on neuropathic pain model by IP EM 1.
作者 李正红 李娟莉
机构地区 蚌埠医学院生理学教研室
出处 《蚌埠医学院学报》 CAS 2002年第6期478-480,共3页 Journal of Bengbu Medical College
关键词 内啡肽类 镇痛 Μ-阿片受体 大鼠 神经源性疼痛模型 endorphins analgesia μ opioid receptor rats,neuropathic pain model
分类号 R971.9 [医药卫生—药品]
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参考文献13

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同被引文献12

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蚌埠医学院学报
2002年 第6期

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