肾组织白细胞介素-2测定与增生性肾炎病理改变相关分析

Relationship between renal interleukin-2 concentrations and pathological changes in proliferative glomerulonephritis

目的 探讨白细胞介素 - 2 (IL- 2 )在增生性肾小球肾炎 (PGN)发病中的作用 .方法 采用放射免疫分析法检测 2 4例 PGN、12例非 PGN患者及 13例正常人血清、尿液和肾活检组织 IL- 2含量 .结果 PGN组肾组织、尿 IL- 2含量显著高于非 PGN和正常对照组 ;肾组织 IL - 2含量愈高 ,肾小球病理改变程度愈重 ;尿 IL - 2含量与肾组织 IL - 2含量正相关 ,与血清 IL- 2含量无平行关系 .结论 IL- 2可能与 PGN发病机制有关 ,尿 IL- 2含量测定可反映肾组织局部 IL-

AIM Studies in vitro has revealed the effect of interleukin 2 (IL 2) in the pathogenesis of proliferative glomerulonephritis (PGN). METHODS Twenty four patients with PGN and twelve non PGN were included in this study. Thirteen healthy person were included as normal control The concentrations of IL 2 in serum, urine and renal biopsy tissues was detected by using immunofluorescence assay. RESULTS The IL 2 concentrations of renal tissues and urine in patients with PGN is much higher than that in patients with non PGN and in normal control, and the concentrations correlated with the extent of glomerular histological changes. There was correlationship between urinary andrenal IL 2 level, and was no correlation ship between uninary and setum IL 2 level. CONCLUSION IL 2 might be involved in the pathogenesis of PGH, and its content in urine can indicate its content in the kidneys.