结直肠癌的表观遗传学研究进展

Epigenetic research progress in colorectal cancer

结直肠癌是常见的恶性肿瘤之一,其发病率和病死率在各种恶性肿瘤中分别居第3和第2位,严重威胁人类健康。结直肠癌的发生与发展是一个涉及遗传和表观遗传变化累积的复杂过程。表观遗传学改变主要包括DNA甲基化、组蛋白修饰、非编码RNAs(如microRNAs和lncRNAs)等,其对结直肠癌的早期诊断、预后评估及化学药物治疗敏感性评估有重要意义,为结直肠癌的治疗提供了新思路。

Colorectal cancer is one of the common malignant tumors,which seriously threatens human health.Its morbidity and mortality rank the third and the second among all malignant tumors.The progress of colorectal cancer is a complex process involving the accumulation of genetic and epigenetic changes.Epigenetic changes of colorectal cancer mainly include DNA methylation,histone modification,non-coding RNAs(such as microRNAs and lncRNAs),which are of great significance to early diagnosis and prognosis evaluation,and to chemosensitivity assessment for colorectal cancer,providing a new thought for the treatment of colorectal cancer.