慢性肝病湿热证与肠道微生态的关联性

Thoughts on the Relationship Between Damp-heat Syndrome of Chronic Liver Disease and Intestinal Microecology

湿热证是常见临床证候,伴见特定胃肠道症状,提示湿热证患者潜在独特的肠道微生态特征,阐释湿热证的物质基础和病理机制对于阐释中医证候的内涵具有重要意义。现以常见慢性肝病为例,提出湿热证肠道微生态的研究要立足于临床,设立好对照,通过同病异证、异病同证的比较探求湿热证的特性和共性;并借助无菌小鼠菌群移植等现代科技手段,探讨肠道微生态与湿热证候的因果关系。以期抛砖引玉,为证候研究探索有效方法。

Damp-heat syndrome is a common clinical syndrome accompanied by specific gastrointestinal symptoms,suggesting the potential unique intestinal microecological characteristics of patients with damp-heat syndrome.Explaining the material basis and pathological mechanism of damp-heat syndrome is of great significance for interpreting the connotation of traditional Chinese medicine(TCM)syndromes.Taking common chronic liver disease as an example,authors put forward that the research on intestinal microecology of damp-heat syndrome should be based on clinical practice and set up a control group,meanwhile the characteristics and similarities of damp-heat syndrome should be explored through the comparison of different syndromes of the same disease and the same syndrome of different diseases.The authors also believe that the causal relationship between intestinal microecology and damp-heat syndrome can be explored through modern scientific and technological means such as flora transplantation in sterile mice,which can provide an effective method for syndrome research and exploration.