模拟急性低压性低氧对小鼠部分血气指标的影响

Effects of Simulated Acute Hypobaric Hypoxia on Some Blood Gas Indices in Mice

为了阐明在模拟急性低压性低氧环境下血气指标的变化趋势,选取BALB/c小鼠作为研究对象,检测了模拟急性低压性低氧时其血液中动脉与静脉的血氧饱和度、氧分压、二氧化碳分压等血液指标的变化。结果表明:随着缺氧时间的延长,BALB/c小鼠动、静脉血氧饱和度差值逐渐增大,24 h后趋于平衡;动、静脉氧分压差随着缺氧时间的延长表现为先降低后增加的趋势;动、静脉二氧化碳分压差随着缺氧时间延长表现为先增加后降低的趋势。该种动态变化主要是由于BALB/c小鼠随着缺氧时间延长,代偿性提高氧的供应、提高氧的利用效率,达到适应缺氧环境的目的。

In order to characterize the changing trend of blood gas indices in simulated acute hypobaric hypoxia environment, the BALB/c mice were selected in this study to observe the variation of oxygen saturation, oxygen partial pressure, carbon dioxide partial pressure in arteries and veins blood when the acute hypobaric hypoxia was simulated. The results showed that with the prolongation of exposure time to anoxic environment, the difference of blood oxygen saturation between arteries and veins in BALB/c mice was increased gradually and reached equilibrium after a 24-hour exposure. The difference between arterial and venous oxygen partial pressure showed a trend of decreasing first and then increasing with the prolongation of exposure time to anoxic environment, and that between arterial and venous carbon dioxide partial pressure changed in the opposite trend. The mechanisms associated with the above dynamic change in blood gas indices in BALB/c mice was that with the prolongation of exposure time to anoxic environment, the supply and utilization efficiency of oxygen was compensatively improved so as to adapt to the hypoxic environment.