自身免疫性肝炎患者血清腺苷脱氨酶水平与肝组织学的关系

Relationship between Serum Adenosine Deaminase Level and Liver Histology in Patients with Autoimmune Hepatitis

目的探讨自身免疫性肝炎患者血清腺苷脱氨酶(ADA)水平与肝组织学的关系。方法以2017年1月—2018年10月为时限,择取该院肝炎科收治的63例自身免疫性肝炎患者为实验组,同期63名健康体检志愿者为对照组,测定并观察两组以及实验组不同肝组织炎症活动程度和肝纤维化程度患者的血清ADA水平。结果实验组ADA(27.1±10.3)U/L高于对照组ADA(12.3±4.1)U/L,差异有统计学意义(t=7.35,P<0.05)。实验组轻度、中度、重度肝炎活动患者ADA分别为(16.7±3.0)U/L、(24.4±6.9)U/L、(31.4±8.2)U/L,Spearman分析示两者呈显著相关性(r=0.89,P<0.05)。结论血清ADA水平与自身免疫性肝炎患者炎症活动度存在相关性,可作为预测和监测免疫性肝炎肝组织学活动的生物标志物加以推广使用。

Objective To investigate the relationship between serum adenosine deaminase(ADA)level and liver histology in patients with autoimmune hepatitis.Methods From January 2017 to October 2018,63 patients with autoimmune hepatitis were selected as experimental group and 63 healthy volunteers were selected as control group.The levels of serum adenosine deaminase of the control group and of the patients with different degrees of liver inflammation and liver fibrosis in the experimental group were measured and observed.Results The ADA(27.1±10.3)U/L of the experimental group was higher than that of the control group(12.3±4.1)U/L,and the difference was statistically significant(t=7.35,P<0.05).The ADA of mild,moderate and severe active hepatitis patients in the experimental group were(16.7±3.0)U/L,(24.4±6.9)U/L and(31.4±8.2)U/L,respectively.Spearman analysis showed that there was a significant correlation between them(r=0.89,P<0.05).Conclusion Serum ADA level is correlated with the degree of inflammation in patients with autoimmune hepatitis.It can be used as a biomarker for predicting and monitoring the histological activity of liver in patients with autoimmune hepatitis.