呼气试验在炎症性肠病诊治中的应用

The application of breath test in diagnosis and treatment of inflammatory bowel disease

炎症性肠病是一类病因和发病机制均尚未十分明了的肠道炎症性疾病,包括溃疡性结肠炎和克罗恩病。近年来的研究发现,肠道菌群紊乱在炎症性肠病的发病过程中起着重要作用,是炎症性肠病发病的始动和持续因素。小肠细菌过度生长在炎症性肠病患者中较为常见。本文概要介绍检测小肠细菌过度生长的乳果糖呼气试验和评估肠道慢性炎症程度的呼气中一氧化氮丰度检测在炎症性肠病诊治中的应用与临床意义。

Inflammatory bowel disease(IBD)is composed of Crohn’s disease and ulcerative colitis.The incidence and prevalence of IBD in our country are continuously increasing while the etiology is still unclear.Recent studies have indicated microbiota dysbiosis played important roles in IBD while small intestinal bacterial overgrowth(SIBO)is common in IBD patients.This review summarizes the prevalence of SIBO in IBD and its relationships between exhaled nitric oxide and systemic chronic inflammation of the intestine.Meanwhile,the application and clinical significance of breath test and nitric oxide breath analysis in the diagnosis and treatment of IBD are also reviewed.