血清胆红素水平与冠心病关系的探讨

Investigation of the relationship between serum bilirubin levels and coronary heart disease

目的:比较冠心病患者与非冠心病患者、不同性别及不同病变程度冠心病患者血清胆红素水平,分析血清胆红素水平与冠心病之间的关系。方法:收集行冠状动脉造影检查患者321例,根据造影结果分为冠心病组168例及对照组153例。根据病变程度将冠心病组患者分为单支病变组58例、双支病变组57例、多支病变组53例。采用重氮法测定两组患者血清总胆红素、直接胆红素、间接胆红素水平。结果:冠心病组患者上述指标均低于对照组;男性冠心病患者上述指标均高于女性冠心病患者;多支病变组患者上述指标水平均低于单支病变组和双支病变组患者。差异均有统计学意义(P<0.05)。结论:血清胆红素水平降低可能较易发生冠心病,随病变严重程度的逐渐加重,血清胆红素水平也随之降低。

Objective:To compare the serum bilirubin levels between the patients with or without coronary heart disease(CHD),the different genders and the different pathological degrees and analyze the relationship between serum bilirubin levels and coronary heart disease.Methods:Three hundred and twenty-one inpatients who underwent coronary angiography were collected and divided into a control group with 153 cases and a coronary heart disease group with 168 cases according to the results of coronary angiography and the later was further divided into a single vessel lesion subgroup(58 cases),a double vessel lesion subgroup(57 cases)and a multiple vessel lesion subgroup(53 cases)based on the degree of lesion.Serum total bilirubin(TBIL),direct bilirubin(DBIL)and indirect bilirubin(IBIL)levels were determined by diazotization.Results:These indicators mentioned above were lower in the CHD group than the control groups,were higher in male patients with CHD than female patients with CHD and were lower in the multiple vessel disease subgroup than the single and double vessel disease subgroups(P<0.05).Conclusion:The reduction of serum bilirubin level may be more prone to coronary heart disease and serum bilirubin levels will be reduced with the gradual increase of the severity of the disease.