摘要
儿童分化型甲状腺癌(children differentiated thyroid cancer,cDTC)的病理生理、临床特征及远期预后与成人DTC(adult DTC,aDTC)均存在较大差异,以往的指南及其证据多基于aDTC证据的推荐,2015年美国甲状腺协会(American Thyroid Association,ATA)发布的cDTC诊治指南在一定程度上填补了目前cDTC临床决策指导的空白。就cDTC的病理及预后特征、风险分层、术后评估、131I治疗决策及随访对该儿童指南进行解读,并纳入近年来有关cDTC的研究证据对指南部分内容加以补充说明。
Compared with adults differentiated thyroid cancer(aDTC),children differentiated thyroid cancer(cDTC)exhibit differences in pathophysiology,clinical presentation,and long-term outcomes.However,previous guidelines for the management of thyroid nodules and cancers were based on the evidence of aDTC.The American Thyroid Association(ATA)children guidelines provide recommendations for the evaluation and management of cDTC to help guide the clinical decisions.This article interprets the pathology and clinical outcomes of cDTC,risk stratification,postoperative assessments,decisions regarding 131I therapy and follow-up in ATA children guidelines as well as updated literature about cDTC in recent years.
作者
杨珂
郑容
林岩松
YANG Ke;ZHENG Rong;LIN Yansong(Department of Nuclear Medicine,Cancer Hospital,Chinese Academy of Medical Sciences,Beijing,100021,China;Department of Nuclear Medicine,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China)
出处
《中国癌症杂志》
CAS
CSCD
北大核心
2019年第6期401-411,共11页
China Oncology
基金
国家自然科学基金(81571714和81771875)
亚洲-太平洋甲状腺研究组项目~~
关键词
儿童甲状腺癌指南
分化型甲状腺癌
131I治疗
研究进展
Management guidelines for children with thyroid cancer
Differentiated thyroid cancer
Radioactive iodine therapy
Research progress
