细胞器互作分子机制及其在疾病发生发展中的作用

Advances in molecular mechanisms of organelle interaction and their role in disease development

细胞器有其特殊的功能,且同时细胞器之间会发生相互作用,通过相互协调来完成一系列重要生理功能。细胞器的相互作用通常发生在膜接触位点(membrane contact sites,MCSs),其中以膜性细胞器内质网最为核心,膜接触位点上特定的束缚蛋白与细胞器膜结合,各种蛋白质复合物协同工作,执行特定的功能,例如脂质转运、Ca^ 2+的转移等。本文综述了近年来关于膜接触位点的结构和功能及其在细胞器中的关键作用研究,主要关注内质网与质膜、线粒体和高尔基体之间的连接,以及膜接触位点上的关键蛋白与各种疾病发生发展的关联。

Organelles have their special functions,they interact with each other and coordinate a series of important physiological functions at the same time.Organelle interaction occurs at membrane contact sites(MCSs),where the membranous organelle endoplasmic reticulum is the core,and specific tethered proteins at the membrane contact site bind to the organelle membrane and various protein complexes work together to perform specific functions,such as lipid transport,Ca^2+transfer,etc.This review studies on the structure and function of membrane contact sites and their key roles in organelle interactions,focusing on the connection between the endoplasmic reticulum and plasma membrane,mitochondria and Golgi,as well as the association between the key proteins at membrane contact sites and the occurrence and development of various diseases.