摘要
神经炎症参与了多种与认知功能障碍相关的中枢系统疾病的发病过程,且大量研究表明神经炎症参与调节了主要包括学习记忆能力与情绪在内的认知功能。本文通过总结不同疾病动物模型及临床数据探讨神经炎症与学习记忆能力及情绪的关系,并探讨了以神经炎症作为治疗手段研究的靶点用于改善疾病认知功能障碍的研究进展,并对此进行了讨论与展望,从而对中枢神经系统疾病引起的认知功能障碍的研究及其治疗药物的研发进一步提供理论指导。
Dysfunctional learning and memorization ability as well as emotion exist in multiple central nervous diseases,which are disastrous to patients and their family.Reports indicate that neuro-inflammation is involved in various central nervous diseases;additionally,it participates in the regulation of learning and memorization ability as well as emotion.This article reviews data on several human diseases of animal model and clinical researches and discusses the relationship between neuro-inflammation and cognitive function.Some therapeutic researches targeting neuro-inflammation to improve neurological diseases are also summarized,with an attempt to provide inspiration and advice for the to development of drugs for diseases alike.
作者
赵梦琦
廖红
ZHAO Mengqi;LIAO Hong(Jiangsu Key Laboratory of Drug Screening,China Pharmaceutical University,Nanjing 210009,China)
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2019年第4期497-504,共8页
Journal of China Pharmaceutical University
基金
国家自然科学基金资助(No.81772063,No.81572240)~~
关键词
神经炎症
认知功能
神经退行性疾病
neuro-inflammation
cognitive function
neurodegenerative diseases