神经炎症与疾病中的认知功能障碍的关系研究进展

Researches progress of the relationship between neuro-inflammation and cognitive function

神经炎症参与了多种与认知功能障碍相关的中枢系统疾病的发病过程,且大量研究表明神经炎症参与调节了主要包括学习记忆能力与情绪在内的认知功能。本文通过总结不同疾病动物模型及临床数据探讨神经炎症与学习记忆能力及情绪的关系,并探讨了以神经炎症作为治疗手段研究的靶点用于改善疾病认知功能障碍的研究进展,并对此进行了讨论与展望,从而对中枢神经系统疾病引起的认知功能障碍的研究及其治疗药物的研发进一步提供理论指导。

Dysfunctional learning and memorization ability as well as emotion exist in multiple central nervous diseases,which are disastrous to patients and their family.Reports indicate that neuro-inflammation is involved in various central nervous diseases;additionally,it participates in the regulation of learning and memorization ability as well as emotion.This article reviews data on several human diseases of animal model and clinical researches and discusses the relationship between neuro-inflammation and cognitive function.Some therapeutic researches targeting neuro-inflammation to improve neurological diseases are also summarized,with an attempt to provide inspiration and advice for the to development of drugs for diseases alike.