不同年龄结肠癌患者血清内CEA、AFP、CA50、CA199和CA724的表达及意义

The Expression and Significance of CEA,AFP,CA50,CA199 and CA724 in Serum of Patients with Colon Cancer at Different Age

目的探讨不同年龄结肠癌患者血清内CEA、AFP、CA50、CA199和CA724表达及临床意义。方法60例结肠癌患者按年龄分为3组:青年组、中年组和老年组,并选取同期健康体检患者20例为对照组,结肠良性病变患者20例为良性组。检测各组血清中CEA、AFP、CA50、CA199和CA724水平变化,并进行统计分析。结果与对照组和良性病变组相比,结肠癌患者血清内AFP、CEA、CA50、CA199和CA724浓度明显升高,差异具有统计学意义(P<0.05)。随着患者年龄的增大,结肠癌患者血清内AFP,CEA,CA50,CA199和CA724浓度呈逐渐上升趋势,差异具有统计学意义(P<0.05)。青年组、中年组和老年组结肠癌患者血清内AFP,CEA,CA50,CA199和CA724检出率具有明显差异,随着患者年龄的升高,结肠癌患者血清可检出人数明显增多,差异具有统计学意义(P<0.05)。不同年龄阶段结肠癌患者血清内AFP,CEA,CA50,CA199和CA724检测的灵敏度、阳性预测值/特异性以及准确度显著高于各指标的标准,阴性预测值低于各指标的单独检测值(P<0.05)。结论不同年龄阶段结肠癌患者血清内CEA、AFP、CA50、CA199和CA724含量及阳性率有显著性差异,老年组患者血清内肿瘤标志物含量最高。

Objective To investigate the expression and clinical significance of CEA,AFP,CA50,CA199 and CA724 in serum of colon cancer patients of different ages.Methods 60 patients with colon cancer were divided into 3 groups according to age:youth group,middle-aged group and elderly group,and 20 cases of healthy patients were selected as the control group,20 cases of benign colon lesions were selected as the benign group.The serum levels of CEA,AFP,CA50,CA199 and CA724 in each group were detected and statistically analyzed.Results Compared with the control group and the benign lesion group,the serum concentrations of AFP,CEA,CA50,CA199 and CA724 in colon cancer patients were significantly increased,there had statistically significant differences(P<0.05).With the increase of age,the serum concentrations of AFP,CEA,CA50,CA199 and CA724 in colon cancer patients presented a gradually increasing trend,and the difference was statistically significant(P<0.05).There were significant differences in the detection rates of AFP,CEA,CA50,CA199 and CA724 in the serum of colon cancer patients in the youth group,the middle-aged group and the elderly group.As the age of the patients increased,the number of serum detectable of colon cancer patients increased significantly,and the difference was statistically significant(P<0.05).The sensitivity,positive predictive value/specificity and accuracy of AFP,CEA,CA50,CA199 and CA724 in serum of colon cancer patients of different ages were significantly higher than the standard of each indicator,while the negative predictive value was lower than the individual detection value of each indicator(P<0.05).Conclusion There are significant differences in serum CEA,AFP,CA50,CA199 and CA724 levels and positive rates among patients with colon cancer at different ages.