液体过负荷与急性肾损伤

Fluid overload and acute kidney injury

肾脏是一个重要的“血流动力学器官”,除了受疾病本身影响外,也极易受血流动力学紊乱的影响。急性肾损伤(AKI)的发生发展过程中,血流动力学紊乱都是一个非常重要的诱发或者加重因素。其中液体过负荷是当今最常见和应当重视的关键因素之一。液体过负荷,既是AKI的结果,也可以是其发生的原因及持续加重的重要因素。液体过负荷可能通过多种机制促成AKI的发生或进一步进展,而AKI患者也容易进一步出现液体过负荷,并通过对其他脏器的相互影响,导致AKI加重及多脏器障碍的恶性循环。防控液体过负荷贯穿整个治疗的全程。

The kidney is an important“hemodynamic organ”that is highly susceptible to hemodynamic disorders as well as various diseases.And hemodynamic disorders can evoke or aggravate acute kidney injury(AKI),among which fluid overload is one of the most common and key factors.It can be caused by AKI,or be the root of the occurrence and deterioration of AKI.Fluid overload may contribute to the occurrence or further progression of AKI through a variety of mechanisms,and lead to multiple organ disorders.Fluid overload prevention and control should be advocated throughout the entire disease course.