乳腺浸润性小叶癌与浸润性导管癌临床病理特征对比分析

Comparison of clinicopathological characteristics between invasive lobular carcinoma and invasive ductal carcinoma

目的对比分析乳腺浸润性小叶癌(ILC)与浸润性导管癌(IDC)的临床病理特征。方法选取乳腺癌患者4 894例,其中ILC组156例,IDC组4 738例。回顾两组患者的性别、年龄、BMI、月经状态、乳房手术方式、腋窝手术方式、T分期、淋巴结是否转移、雌激素受体(ER)、孕激素受体(PR)、类表皮生长因子受体2(Her-2)、Ki-67、乳腺癌病理分子分型情况等。比较两组患者的临床病理特征。结果与IDC组患者比较,ILC组患者年龄较大,ER、PR阳性比例较高,Her-2阳性比例较低,Ki-67<14%的比例较高,两组比较差异均有统计学意义(均P<0.05)。两组患者性别、BMI、月经状态、乳房手术方式、腋窝手术方式、T分期、淋巴结是否转移、转移淋巴结数目等临床病理特征比较差异均无统计学意义(均P>0.05)。结论与IDC患者比较,ILC患者发病年龄较晚,ER、PR阳性比例较高,Her-2阳性比例较低,Ki-67<14%的比例较高。

Objective To compare the clinicopathological features between invasive lobular carcinoma(ILC)and invasive ductal carcinoma(IDC)of the breast.Methods The clinicopathological features of 156 patients with ILC and 4 738 patients with IDC were compared,including the gender,age,BMI,the state of menses,modalities of breast and axillary surgery,T stage,LNM,ER,PR,Her-2,Ki-67,and pathological molecular types.Results Compared with IDC patients,the ILC patients were tended to be older and have higher positive ER,PR and lower positive Her-2 rates;and the ILC patients were more likely to have Ki-67<14%(all P<0.05).There were no statistic differences in gender,BMI,the state of menses,modalities of breast and axillary surgery,T stage and LNM(P>0.05).Conclusion The clinicopathological features of IDC and ILC patients are different in aspects of age,ER,PR,Her-2,and Ki-67 levels.