健脾益肾颗粒和免疫抑制剂治疗慢性肾小球疾病

Clinical effects and adverse reactions of spleen - invigorating kidney granules and immunosuppressive agents in patients with chronic glomerular disease

目的观察慢性肾小球疾病患者采用健脾益肾颗粒和免疫抑制剂治疗的临床效果和不良反应情况。方法选取2016年2月至2017年12月间在河南科技大学第一附属医院就诊的128例慢性肾小球疾病患者,采用随机数表法将患者分为观察组(64例)、对照组(64例)。对照组单独接受免疫抑制剂治疗,观察组接受健脾益肾颗粒和免疫抑制剂治疗。观察比较两组患者的临床疗效、肾功能、不良反应情况。结果观察组治疗总有效率高于对照组(P<0.05);治疗后观察组24 h尿蛋白、血清尿素氮、血清肌酐均低于对照组(均P<0.05),肌酐清除率高于对照组(P<0.05);观察组患者严重水肿、血压增高、肝损伤、肾功能变化的发生率均低于对照组(均P<0.05)。结论采用健脾益肾颗粒和免疫抑制剂治疗慢性肾小球疾病效果显著,可有效改善肾功能。

Objective To observe the clinical effect and adverse reactions of patients with chronic glomerular nephropathy treated with invigorating spleen and kidney granules and immunosuppressive agents.Methods From February 2016 to December 2017,128 patients with chronic glomerular disease admitted to the First Affiliated Hospital of Henan University of Science and Technology were randomly divided into observation group(64 cases)and control group(64 cases)by random number method.Patients in the control group were treated with immunosuppressive agents,while those in the observation group were treated with invigorating spleen and kidney granules and immunosuppressive agents.The clinical efficacy,renal function and adverse reactions of the two groups were observed and compared.Results The total therapeutic efficiency of the observation group was higher than that of the control group(P<0.05).After treatment,urinary protein,serum creatinine and serum urea nitrogen in the observation group were all lower than the control group at 24 h(all P<0.05),and creatinine clearance rate was higher than that of the control group(P<0.05).The incidence of severe edema,high blood pressure,liver injury and renal function changes in the observation group were lower those in the control group(all P<0.05).Conclusion The treatment of chronic glomerulonephritis with invigorating spleen and invigorating kidney granule and immunosuppressant has better clinical effect,which can effectively improve renal function.This method has high clinical value and is worthy of application.