期刊文献+

二甲双胍联合门冬胰岛素治疗妊娠糖尿病 被引量:7

下载PDF
导出
摘要 目的观察二甲双胍联合门冬胰岛素治疗妊娠糖尿病患者的血糖控制效果及对母婴结局的影响。方法将66例妊娠糖尿病患者以随机数表法分为对照组与观察组,各33例。对照组接受门冬胰岛素治疗,观察组接受二甲双胍联合门冬胰岛素治疗。比较两组患者血糖水平控制情况以及母婴结局。结果治疗后两组空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)水平较治疗前均降低(均P<0.05),观察组FPG、2 h PG、HbA1c降低幅度优于对照组,差异有统计学意义(均P<0.05)。观察组妊高症、羊水过多、蛋白尿发生率低于对照组,差异统计学意义(均P<0.05),观察组新生儿黄疸、低血糖、呼吸窘迫及巨大儿发生率低于对照组,差异有统计学意义(均P<0.05)。结论二甲双胍联合门冬胰岛素可有效控制妊娠糖尿病患者血糖水平,改善母婴结局。
作者 吕建利
出处 《河南医学研究》 CAS 2019年第16期2968-2969,共2页 Henan Medical Research
  • 相关文献

参考文献6

二级参考文献52

  • 1谢幸,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013:118-119.
  • 2Gonz~tlez-Quintero V H, Istwan N B, Rhea D J, et alThe impact of glycemic control on neonatal outcome in singleton pregnancies complicated by gestationaldiabetes [ J]. Diabetes Care, 2007,30(3 ) :467-470.
  • 3DCCT Research Group. Pregnancy outcomes in the Dia- betes Control and Complications Trial [ J ]. Am J Obstet Gynecol, 1996,174 ( 4 ) : 1343-1353.
  • 4Lappas M, Mitton A, Permezel M. In response to oxida- tive stress, the expression of inflammatory cytokines and antioxidant enzymes are impaired in placenta, but not ad- ipose tissue, of women with gestational diabetes [ J ]. J Endocrinol, 2010,204 ( 1 ) :75-84.
  • 5Werner EF, Pettker CM, Zuckerwise L, et al. Screening for gestational diabetes mellitus:are the criteria proposed by the international association of theDiabetes and Pregnancy Study Groups cost-effective? [ J ]. Diabetes Care ,2012,35 (3) :529- 535.
  • 6Lowe LP,Metzger BE,Dyer AR,et al. Hyperglycemia and Ad- verse Pregnancy Outcome (HAPO) Study: associations of ma- ternal A1 C and glucose withpregnancy outcomes[ J ]. Diabetes Care ,2012,35 (3) :574-580.
  • 7Ishibashi Y,Matsui T,Takeuchi M,et al. Mefformin inhibits advanced glycation end products(AGEs)-induced renal tubu- lar cell injury by suppressing reactive oxygen species genera- tion via reducing receptor for AGEs (RAGE) expression[J]. Horm Metab Res,2012,44(12) :891-895.
  • 8Mitrovic M, Stojic S, Tesic DS, et al. The impact of diabetes mellitus on the course and outcome of pregnancy during a 5- year follow-up[J]. Vojnosanit Pregl ,2014 ,71 (10) :907-914.
  • 9Tundidor D, Garcia-Patterson A, Maria MA, et al. Perinatal maternal and neonatal outcomes in women with gestational diabetes meUitus according to fetal sex [ J ]. Gend Med, 2012,9(6) :411-417.
  • 10Hadar E, Hod M. Establishing consensus criteria for the diag- nosis of diabetes in pregnancy following the HAPO study [J]. Ann N Y Acad Sci,2010,1205:88-93.

共引文献199

同被引文献91

二级引证文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部