浆细胞骨髓瘤的临床病理特征分析

Analysis on clinicopathological characteristics of plasma cell myeloma

目的探讨浆细胞骨髓瘤(PCM)的临床病理特征、免疫表型、诊断及鉴别诊断。方法回顾性分析10例PCM患者临床病理资料、组织学形态及免疫表型。结果PCM患者常因贫血、骨痛、乏力等原因就诊,骨髓穿刺活检是诊断PCM的重要方法。肿瘤性浆细胞在骨髓中的分布可呈间质型、结节型或塞实型3种模式。根据细胞形态将PCM分为高、中、低分化3种类型。结论PCM临床症状复杂多样,当患者出现贫血、骨痛、乏力等症状时应注意排查PCM,而骨髓穿刺活检并结合免疫组织化学检查是诊断PCM必不可少的手段。

Objective To study the clinicopathological feathers,immunophenotype,diagnosis and differentiation diagnosis of plasma cell myeloma(PCM).Methods The clinicopathologic data,histological morphology and immunophenotype in 10 patients with PCM were retrospectively analyzed.Results Usually the patients consulted doctor because of anemia,bone pain,weakness and so on.Bone marrow biopsy was an important method to diagnose PCM,the distribution of neoplastic plasma cells in bone marrow could show the three patterns of interstitial type,nodular type or solid type.Based on the cellular morphology,PCM was divided into high differentiated,moderate differentiated and low differentiated types.Conclusion The clinical symptoms of PCM are complex and diverse,and when the patients appear the symptoms of anemia,bone pain and weakness,which should pay attention to check PCM,while bone marrow puncture biopsy assisted with immunohistochemical examination is an essential mean to diagnose PCM.