门诊老年2型糖尿病合并甲状腺功能异常患者的临床特点分析

Clinical characteristics investigation in elderly outpatients with type 2 diabetes mellitus complicating thyroid dysfunction

目的探讨门诊老年2型糖尿病合并甲状腺功能异常患者的临床特点。方法随机选取2017年5月至2018年5月在该院门诊就诊的1 000例老年2型糖尿病患者,根据甲状腺功能是否异常分为甲状腺疾病组(125例)、非甲状腺疾病组(875例),对两组年龄、体质量指数(BMI)、空腹血糖(FPG)、全血糖化血红蛋白(HbA1c)、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平以及甲状腺自身免疫抗体阳性率进行比较。结果甲状腺疾病组的BMI明显高于非甲状腺疾病组(P<0.05),甲状腺疾病组的HbA1c、FPG水平与非甲状腺疾病组比较,差异无统计学意义(P>0.05);非甲状腺疾病组患者血清TC、TG水平明显低于甲状腺疾病组(P<0.05),非甲状腺疾病组患者与甲状腺疾病组患者血清LDL-C、HDL-C水平比较,差异无统计学意义(P>0.05)。在门诊老年2型糖尿病合并甲状腺功能异常患者中,男性甲状腺自身免疫抗体阳性率明显低于女性(P<0.05)。门诊老年2型糖尿病男性患者甲状腺疾病的患病率明显低于女性患者(P<0.05)。结论门诊老年2型糖尿病合并甲状腺功能异常患者中女性甲状腺疾病患病率高于男性,对于2型糖尿病血脂异常患者需要定期进行甲状腺功能检查。

Objective To investigate the clinical characteristics of elderly outpatients with type 2 diabetes mellitus(T2DM)complicating thyroid dysfunction.Methods A total of 1 000 elderly outpatients with T2DM were randomly selected in the outpatient department of this hospital from May 2017 to May 2018.According to the abnormality of thyroid function,the patients were divided into thyroid disease group(125 cases)and non-thyroid disease group(875 cases),and the age body mass index(BMI),fasting blood glucose(FPG),total glycosylated hemoglobin A1c(HbA1c),total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)and positive rate of thyroid autoimmune antibody were compared between the thyroid disease group and non-thyroid disease group.Results BMI of the thyroid disease group was significantly higher than that of the non-thyroid disease group(P<0.05).There was no statistically significant difference in HbA1c and FPG between the thyroid disease group and non-thyroid disease group(P>0.05).The levels of serum TC and TG in the non-thyroid disease group were significantly lower than those in the thyroid disease group(P<0.05).Serum LDL-C and HDL-C levels had no statistical difference between the non-thyroid disease group and thyroid disease group(P>0.05).In elderly patients with T2DM complicating thyroid dysfunction,the positive rate of thyroid autoimmune antibody in male patients was significantly lower than in females(P<0.05).The prevalence rate of thyroid diseases in male patients of elderly outpatients with T2DM was significantly lower than that in female patients(P<0.05).Conclusion The prevalence of thyroid disease of female outpatients with T2DM complicating thyroid dysfunction is higher than that of male outpatients.The T2DM patients with dyslipidemia need to conduct regular thyroid function examination.