普伐他汀治疗高血压伴血脂紊乱老年患者的效果

Effects of Pravastatin in treatment for elderly patients with hypertension and lipid disorders

目的:探讨普伐他汀治疗高血压伴血脂紊乱老年患者的临床效果。方法:选取高血压伴血脂紊乱老年患者188例,采用随机数字表法将其分为观察组和对照组各94例。对照组实施常规疗法,观察组采用普伐他汀治疗。比较两组治疗前后的血压、血脂(TC、TG、LDL-C、HDL-C)、冠状动脉钙化积分、颈动脉内膜中层厚度,统计两组不良反应发生率。结果:治疗后,观察组收缩压、舒张压、TC、TG、LDL-C、冠状动脉钙化积分、颈动脉内膜中层厚度均低于对照组,HDL-C水平高于对照组,差异均有统计学意义(P<0.05)。结论:普伐他汀治疗高血压伴血脂紊乱老年患者的效果显著,可改善患者的血脂和动脉钙化状况。

Objective: To investigate clinical effects of Pravastatin in treatment for elderly patients with hypertension and lipid disorders.Methods: 188 elderly patients with hypertension and lipid disorders were selected and divided into observation group and control group according to the random number table, 94 cases in each. The control group received conventional therapy, while the observation group was treated with Pravastatin. The blood pressure, blood lipids(TC, TG, LDL-C, and HDL-C), coronary artery calcification score, and carotid intima-media thickness were compared before and after the treatment. The incidence of adverse reactions was statistically analyzed. Results: After the treatment, the systolic blood pressure, diastolic blood pressure, TC, TG, LDL-C, coronary artery calcification score, and carotid intima-media thickness were lower in the observation group than in the control group;the HDL-C level was higher than that of the control group;and the differences were statistically significant(P<0.05). Conclusions: Pravastatin has significant effects in the treatment of the elderly patients with hypertension and lipid disorders.Moreover, it can improve the blood lipid and arterial calcification conditions.