喹硫平联合碳酸锂治疗双相障碍抑郁发作的效果观察

Effects of Quetiapine combined with Lithium carbonate on depressive episodes of bipolar disorder

目的:观察喹硫平联合碳酸锂治疗双相障碍抑郁发作的临床效果。方法:选取64例双相障碍抑郁发作患者作为研究对象,依据随机数字表法将其分为观察组和对照组各32例,对照组单纯采用碳酸锂治疗,观察组在对照组的基础上联合喹硫平治疗,比较两组入院时和治疗后第1、2、4、8周末的抑郁评分、精神症状严重程度及不良反应发生情况。结果:治疗后观察组汉密尔顿抑郁量表(HAMD-17)评分、阳性与阴性症状量表(PANSS)评分均明显低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:喹硫平联合碳酸锂治疗双相障碍抑郁发作的临床效果更显著,可有效改善患者的抑郁症状,且不会增加不良反应。

Objective: To analyze clinical effects of Quetiapine combined with Lithium carbonate in treatment of depressive episodes of bipolar disorder. Methods: Sixty-four patients with depressive episodes of bipolar disorder were selected as the study objects and divided into observation group and control group according to the random number table method, 32 cases in each group. The control group was treated with Lithium carbonate alone, while the observation group was treated with Quetiapine on the basis of that of the control group. The depression scores before and 1, 2, 4 and 8 weeks after the admission, the severity of mental symptoms and the adverse reactions were compared between the two groups.Results: After the treatment, the Hamilton depression scale(HAMD-17) score and the positive and negative symptom scale(PANSS) score in the observation group were significantly lower than those in the control group, and the differences were statistically significant(P<0.05). The incidence of adverse reactions in the two groups was statistically significant(P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups. Conclusions: Quetiapine combined with Lithium carbonate in the treatment of depressive episodes of bipolar disorder has a good clinical effect, and can effectively improve the depression symptoms of the patients without increasing the incidence of adverse reactions.