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阿齐沙坦的波谱学数据及结构确证 被引量:6

Spectral Analyses and Structural Elucidation of Azilsartan
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摘要 阿齐沙坦为新一代选择性AT-1亚型血管紧张素II受体拮抗剂类抗高血压药,具有降压平稳、不引起干咳等优点,有较好的市场前景.本文对阿齐沙坦的紫外吸收光谱(UV)、红外吸收光谱(IR)、高分辨质谱(HRMS)、核磁共振(NMR)波谱(包括1H NMR、13C NMR、DEPT、1H-1H COSY、HMQC、HMBC)数据进行了解析和归属,综合运用多种谱学方法确证了阿齐沙坦的结构. Azilsartan is a novel AT-1 angiotensin II receptor blocker,which reduces blood pressure mildly without the side effect of cough.The drug is believed to have a large market potential.In this study,the drug was analyzed by ultraviolet spectroscopy(UV),infrared spectroscopy(IR),high resolution mass spectrometry(HRMS)and one-/two-dimensional magnetic resonance spectroscopy(i.e.,1H NMR,13C NMR,DEPT,1H-1H COSY,HMQC and HMBC).The spectral data were carefully analyzed,interpreted and used to elucidate the structure of the compound.
作者 王亚兰 王晓静 王志伟 WANG Ya-lan;WANG Xiao-jing;WANG Zhi-wei(School of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan 250200,China;Ministry of Health Key Laboratory for Biotech and Drugs,Institute of Materia Medica,Shandong Academy of Medical Sciences,Jinan 250062,China;Shandong Analysis and Test Center,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250014,China)
出处 《波谱学杂志》 CAS 北大核心 2019年第3期350-358,共9页 Chinese Journal of Magnetic Resonance
基金 国家自然科学基金资助项目(31700290) 山东省医学科学院医药卫生科技创新工程
关键词 核磁共振(NMR) 归属 化学位移 阿齐沙坦 结构确证 nuclear magnetic resonance(NMR) assignment chemical shift azilsartan structure elucidation
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