摘要
目的系统评价葛根素注射液改善心律失常的有效性。方法计算机检索PubMed、中国生物医学文献数据库(CBM)、中国期刊全文数据库(CNKI)、万方期刊数据库等文献数据库,检索并筛选有关葛根素注射液联合基础治疗与单纯基础治疗心律失常的随机对照试验(RCTs)。按照Cochrane Library Handbook推荐的质量评价方法对纳入文献进行方法学质量评价。并采用RevMan5.3软件对数据进行Meta分析。结果共纳入11篇文献,包含1253例病人,Meta分析结果提示:在缓解心律失常的临床症状方面[OR=4.03,95%CI(2.72,5.95),P<0.000 01]以及改善心电图疗效方面[OR=2.63,95%CI(2.00,3.45),P<0.000 01)],葛根素注射液联合基础治疗的有效率均高于单纯基础治疗。结论葛根素注射液联合基础治疗可改善病人心律失常,受纳入研究方法学质量限制,该结论有待高质量、大样本的长期RCTs进一步验证。
Objective To evaluate the efficacy of Puerarin injection in the treatment of arrhythmia.Methods The literatures were retrieved from China journal full-text database(CNKI),the Chinese biomedical database,and PubMed.The randomized-controlled trails(RCT)about treatment of arrhythmia with Puerarin injection and standard treatment were collected.Methodological quality evaluations of included literature were conducted according to the methods recommended by Cochrane Library Handbook.The relevant data were statistically analyzed by Meta analysis with RevMan 5.3 software.Results Eleven literatures and 1 253 patients were included.Meta analysis results showed that Puerarin injection could significantly improve the clinical efficacy[RR=4.03,95%CI(2.72,5.95),P<0.000 01]and efficacy of electrocardiogram[RR=2.63,95%CI(2.00,3.45),P<0.000 01].Conclusion Puerarin injection could improve the clinical efficacy of arrhythmia.
作者
冯倩
程嵩奕
陈道海
杨璇妹
陈晓虎
俞鹏
FENG Qian;CHENG Songyi;CHEN Daohai;YANG Xuanmei;CHEN Xiaohu;YU Peng(School of Medicine and Life Science,Nanjing University of Chinese Medicine,Nanjing 210023,Jiangsu,China)
出处
《中西医结合心脑血管病杂志》
2019年第15期2259-2263,共5页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
国家自然科学基金(No.81573908)
江苏省自然科学基金(No.BK20171099)