阿托伐他汀联合普罗布考对脑梗死患者Ox-LDL及疗效的影响

Effects of atorvastatin combined probucol on ox-LDL and curative effects in patients with cerebral ischemia

目的研究阿托伐他汀联合普罗布考治疗急性脑梗死的疗效及对患者血脂、氧化低密度脂蛋白(ox-LDL)的影响。方法100例急性脑梗死患者随机分为对照组(n=49)和治疗组(n=51),2组在常规治疗的基础上,对照组给予阿托伐他汀20 mg,1次/晚,治疗组给予阿托伐他汀20 mg,每晚1次,加普罗布考0.5 g,2次/d。比较2组治疗前及治疗后第14天的总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、ox-LDL及神经功能缺损评分(NIHSS)评分,治疗前及治疗90 d后改良Rankin量表(mRS)评分,比较2组治疗前后的临床疗效及药品不良反应发生率。结果2组患者治疗第14天后TC、TG、LDL、ox-LDL水平与NIHSS评分均有显著下降(P<0.05),且治疗组治疗第14天的TC、TG、LDL、ox-LDL水平与NIHSS评分均显著低于对照组(P<0.05)。治疗90 d后,治疗组mRS下降水平显著高于对照组(P<0.05)。治疗90 d后2组安全性指标改变差异无统计学意义(P>0.05)。结论阿托伐他汀联合普罗布考联合治疗急性脑梗死疗效优于单用阿托伐他汀,改善脑梗死后神经功能及生活质量,阿托伐他汀联合普罗布考可以在脑梗死二级预防中的作用有待于扩大样本,进一步完善随访,以获得更全面、更具有代表性的资料。

Objective To observe the therapeutic effects of atorvastatin combined with probucol on acute cerebral infarction and its effects on blood lipid and oxidized low-density lipoprotein(ox-ldl)of patients.Methods One hundred patients with acute cerebral infarction were randomly divided into control group(n=49)and treatment group(n=51).On the basis of conventional therapy,the patients in control group were given atorvastatin 20mg,qn,however,the patients in treatment group were given atorvastatin 20mg qn,and probucol 0.5g,bid.The levels of total cholesterol(TC),triglyceride(TG),low-density lipoprotein(LDL),ox-LDL and neurologic impairment score(NIHSS)were observed and compared between the two groups before treatment and at 14 days after treatment,moreover,the modified Rankin scale(mRS)scores,therapeutic effects and incidence rates of adverse reactions were observed and compared were observed and compared between the two groups.Results The levels of TC,TG,LDL,ox-LDL and NIHSS scores in both groups were significantly decreased after 14-day treatment(P<0.05),moreover,the levels of TC,TG,LDL,ox-LDL and NIHSS scores in treatment group were significantly lower than those in control group(P<0.05).After 3-month treatment,the decrease levels of mRS scores in treatment group were significantly higher than those in control group(P<0.05).After 3-month treatment,there were no significant differences in safety indexes between the two groups(P>0.05).Conclusion The therapeutic effects of atorvastatin combined with probucol on acute cerebral infarction are superior to those by simple atorvastatin,and the latter can improve neurological function and life quality of patients.The effects of atorvastatin combined with probucol in secondary prevention of cerebral infarction need to be researched further.