摘要
目的观察化浊解毒方治疗溃疡性结肠炎(UC)的临床疗效。方法收治的120例患者按随机数字表法分为观察组和对照组,每组60例。入组病例共脱落7例,观察组3例(失访),对照组4例(失访)。符合研究方案的病例共113例,其中观察组57例,对照组56例。观察组给予化浊解毒方(水煎服,1剂/d),对照组给予美沙拉嗪肠溶片(每次1 g,3次/d),疗程均为4周,观察治疗前后患者临床症状、生活质量及结肠镜变化。结果与治疗前比较,2组患者接受治疗后各症状积分均下降(P<0.05);治疗后与对照组比较,观察组腹泻、腹痛、里急后重、腹胀积分降低明显(P<0.05)。治疗后治疗组0级、Ⅰ级肠镜例数均多于对照组,差异有统计学意义(P<0.05)。与治疗前比较,治疗后2组患者情感功能、全身症状、肠道症状、社会功能评分及总评分均升高(P<0.05);与对照组比较,观察组治疗后全身症状、情感功能、肠道症状评分及总评分升高(P<0.05)。结论化浊解毒方能够有效缓解UC患者临床症状,改善镜下病理变化,提高患者的生活质量。
Objective To observe the clinical effects of Huazhuojiedu recipe on ulcerative colitis(UC).Methods A total of 120 patients with UC were divided into observation group(n=60)and control group(n=60)according to random number table method.The patients in observation group were treated by Huazhuojiedu recipe(water decoction,one dose a day),however,the patients in control group were treated by mesalazine enteric-coated tablets,1g once,three times a day,with a treatment course of 4 weeks for both groups.The changes of clinical symptoms,life quality of patients and colonoscopy were observed before and after treatment.Results After 4-week treatment,the total effective rate in observation group was 82.46%,which was significantly higher than that(60.71%)in control group.The numbers of patients with grade 0 and gradeⅠin observation group were significantly more than those in control group(P<0.05).There was a significant difference in the overall grade distribution of enteroscopy between the two groups(P<0.05).After treatment,the general symptoms,intestinal symptoms,emotional function,social function scores and total scores of the patients were significantly increased in both groups,as compared with those before treatment(P<0.05),moreover,which in observation group were significantly higher than those in control group(P<0.05).Conclusion Huazhuojiedu recipe can effectively relieve the clinical symptoms of patients with UC,improve the pathological changes under the microscope,and improve the life quality of patients.
作者
李博林
白亚楠
景璇
何芳
梁亚飞
才艳茹
杜朋丽
赵丹阳
杨倩
LI Bolin;BAI Yanan;JING Xuan(Hebei Provincial TCM Hospital,Hebei,Shijiazhuang 050017,China)
出处
《河北医药》
CAS
2019年第17期2635-2638,共4页
Hebei Medical Journal
基金
河北省科技厅重点研发计划自筹项目(编号:182777163)
河北省中医药管理局科研计划项目(编号:2018039)
关键词
溃疡性结肠炎
化浊解毒方
治疗结果
ulcerative colitis
Huazhuojiedu recipe
treatment outcome