儿童阻塞性睡眠呼吸暂停低通气综合征与部分血清生化指标的相关性分析

Correlation Between Obstructive Sleep Apnea Hypopnea Syndrome and Some Serum Biochemical Markers in Children

目的:探讨儿童阻塞性睡眠呼吸暂停低通气综合征与部分血清生化指标的相关性。方法:选取2017年10月至2019年2月湖北省襄阳市谷城县人民医院收治的阻塞性睡眠呼吸暂停低通气综合征患儿64例作为观察组,同时选取同时期64名进行健康体检的儿童作为对照组,分别对2组儿童的血清丙氨酸转移酶(ALT)、血尿素氮(BUN)、总胆固醇(TC)、三酰甘油(TG)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)、空腹血糖(FPG)水平进行检测,观察2组患儿的各项指标差异情况。结果:观察组的ALT、TC、TG、CK-MB、cTnI明显高于对照组,差异有统计学意义(P<0.05);但2组患者的BUN与FPG无统计学意义(P>0.05)。结论:ALT、TC、TG、CK-MB、cTnI的变化与儿童阻塞性睡眠呼吸暂停低通气综合征具有密切关联。

Objective:To investigate the relationship between obstructive sleep apnea hypopnea syndrome and some serum biochemical markers in children.Methods:A Total of 64 children with obstructive sleep apnea hypopnea syndrome admitted to our hospital from October 2017 to February 2019 were enrolled as the experimental group.64 children who underwent physical examination at the same time were selected as the control group.Serum alanine transferase(ALT),blood urea nitrogen(BUN),total cholesterol(TC),triglyceride(TG),creatine kinase isoenzyme(CK-MB),cardiac troponin in the two groups of children The levels of I(cTnI)and fasting blood glucose(FPG)were measured,and the differences between the two groups were observed.Results:The ALT,TC,TG,CK-MB,and cTnI in the experimental group were significantly higher than those in the control group(P<0.05).However,there was no difference in BUN and FPG between the two groups(P>0.05).Conclusion:Changes in ALT,TC,TG,CK-MB,and cTnI are closely associated with childhood obstructive sleep apnea hypopnea syndrome.