抑郁症伴失眠患者甲状腺激素水平的变化研究

Changes of Thyroid Hormone Levels in Patients with Depression and Insomnia

目的:探讨抑郁症伴失眠患者甲状腺激素水平的变化。方法:选取2017年1月至2018年12月山东省淄博市精神卫生中心收治的抑郁症伴失眠患者80例设为观察组,选择同期收治的抑郁症无失眠患者80例设为对照组,检测2组患者甲状腺激素水平并统计甲状腺疾病检出率。观察组治疗4周后,根据PSQI评分分为观察1组(PSQI>7分)42例及观察2组(PSQI≤7分)38例,检出2组患者甲状腺激素水平并统计甲状腺疾病检出率。结果:观察组甲状腺疾病检出率为45.00%,明显高于对照组的28.75%,差异有统计学意义(P<0.05);治疗4周后,观察1组甲状腺疾病检出率为45.24%,明显高于观察2组的23.68%,差异有统计学意义(P<0.05)。结论:抑郁症伴失眠患者甲状腺激素水平异常改变更严重,甲状腺疾病检出率明显增加,提高睡眠质量有助于改善甲状腺激素水平,降低甲状腺疾病检出率。

Objective:To investigate the changes of thyroid hormone levels in patients with depression and insomnia.Methods:A total of 80 patients with depression with insomnia were selected as the study group,and 80 patients with depression without insomnia in the same period were selected as the control group,from January 2017 to December 2018.The levels of thyroid hormones in the two groups were measured and the detection rate of thyroid diseases was counted.After 4 weeks of treatment,the study group was divided into study group 1(PSQI>7)42 cases and study group 2(PSQI≤7)38 cases according to PSQI score.Thyroid hormone level was detected in two groups and the detection rate of thyroid diseases was counted.Results:The detection rate of thyroid diseases in the study group was 45.00%,which was significantly higher than that in control group(28.75%,P<0.05),and after 4 weeks of treatment,the detection rate of thyroid diseases in study group 1 was 45.24%,significantly higher than that in study group 2(23.68%,P<0.05).Conclusion:The abnormal change of thyroid hormone level is more serious in depression patients with insomnia.The detection rate of thyroid disease is increased obviously.Improving sleep quality is helpful to improve thyroid hormone level and reduce the detection rate of thyroid disease.