miR93和miR21联合检测对2型糖尿病视网膜病变进展的预测价值

Prediction of retinopathy in type 2 diabetes mellitus by combined detection of microRNA93and microRNA21

目的:分析血浆微小核糖核酸(miR)-93和miR21联合检测对2型糖尿病视网膜病变(DR)进展的预测价值。方法:选取本院2013-06/2014-06收治的2型DR患者76例,根据随访结果,将患者分成DR非进展组(34例)和DR进展组(42例),另选取45例健康体检者为对照组。检测三组血清中miR93和miR21水平的变化;分析DR患者预后的独立危险因素;分析其对患者预后的预测价值。结果:DR进展组患者血清中miR93和miR21水平明显高于DR非进展组和对照组(均P<0.01);二者可作为影响DR患者病情进展的独立危险因素;两者联合检测曲线下面积、特异度与敏感度均高于单独检测(P<0.05)。结论:miR93和miR21在DR患者血清中增高,影响DR患者病情进展。

AIM:To analyze the predictive value of combined detection of plasma microRNA-93(miR-93)and microRNA-21(miR-21)in the progression of type 2 diabetic retinopathy(DR).METHODS:Totally 76 patients with type 2 diabetic retinopathy admitted to our hospital from June 2013 to June 2014 were divided into DR non-progressive group(34 cases)and DR progressive group(42 cases)according to the follow-up results,and 45 healthy people were selected as the control group.The serum levels of miR93 and miR21 in three groups were detected;the independent risk factors of prognosis in DR patients were analyzed;and the predictive value of miR93 and miR21 in DR patients was analyzed.RESULTS:The serum levels of miR93 and miR21 in DR progressive group were significantly higher than those in non-progressive group and control group(all P<0.01);both of them could be used as independent risk factors affecting the progress of DR patients;the area,specificity and sensitivity under the combined detection curve were higher than those of single detection(P<0.05).CONCLUSION:The serum levels of miR93 and miR21 are increased in DR patients,which can affect the progress of DR patients,and can be used as biomarkers for the diagnosis of DR.