维生素D3辅助治疗儿童咳嗽变异性哮喘临床疗效及对免疫功能的影响

Clinical effect of Vitamin D3 in adjuvant treatment of childhood cough variant asthma and its effect on serum inflammatory factors and immune function

目的探讨维生素D3辅助治疗儿童咳嗽变异性哮喘临床疗效及对免疫功能的影响。方法回顾性分析咳嗽变异哮喘患儿104例,随机分为观察组和对照组各52例,选择原发病治疗相同,观察组加用维生素D3口服,每天800IU/d,疗程3月。比较两组患儿治疗前后临床疗效及对免疫功能指标。结果治疗前两组IgG、IgA、IgM、TNF-α、IL-6、IL-8、FEV 1%、FENO水平差异无统计学意义(P>0.05)。治疗后观察组IgG、IgA、IgM水平及FEV 1%明显高于对照组(P<0.05),维生素D3组TNF-α、IL-6、IL-8水平及FENO水平明显低于对照组(P<0.05)。结论咳嗽变异性哮喘患儿应用维生素D3辅助治疗能减低炎症反应,提高患儿免疫功能并改善肺功能。

Objective To discussed the clinical effect of Vitamin D3 in adjuvant treatment of childhood cough variant asthma and its effect on serum inflammatory factors and immune function.Methods The clinical data of 104 patients with cough variant asthma from July 2016 to July 2017 were retrospectively analyzed,and they were randomly divided into the observation group and the control group,54 cases in each group.All of them were given of conventional drugs,and the observation group was additionally treated with vitamin D3.The changes of immune function,serum inflammatory factors,lung function and FENO were compared.Results There was no significantly difference in IgG,IgA,IgM,TNF-α,IL-6,IL-8,FEV 1%and FENO between the two groups before and after treatment(P>0.05).After treatment,the levels of IgG,IgA and IgM in the observation group were higher than the control group(P<0.05),the levels of TNF-α,IL-6 and IL-8 were lower in the observation group than in the control group(P<0.05),the level of FENO was lower in the observation group than in the control group(P<0.05),and the level of FEV 1%was higher in the observation group than in the control group(P<0.05).Conclusion Vitamin D3 adjuvant treatment for children with cough variant asthma can reduce inflammation and improve immune function and lung function.