孕产妇血清中SHBG、NF-■Bp65、Sfrp-5表达与妊娠期糖尿病关系

The correlation of the expressions of serum SHBG, NF k 65, and Sfrp 5 of pregnant women to their gestational diabetes mellitus occurrence

目的:探讨孕产妇血清中性激素结合球蛋白(SHBG)、人核转录因子p65(NF-κBp65)、卷曲相关蛋白5(Sfrp-5)的表达与妊娠期糖尿病关系。方法:选择2014年2月—2017年2月本院确诊的100例妊娠期糖尿病患者为观察组,选择同期正常妊娠妇女80例为对照组,测定血清SHBG、NF-κBp65、Sfrp-5水平。结果:观察组空腹及餐后30min、1h、2h时血糖水平均高于对照组,餐后30min、2h时胰岛素水平低于对照组(均P<0.05);观察组血清SHBG、Sfrp-5水平低于对照组,NF-κBp65水平高于对照组(P<0.05);相关性分析,SHBG、Sfrp-5与血糖和胰岛素均呈负相关,NF-κBp65与血糖和胰岛素均呈正相关(均P<0.05)。结论:妊娠期糖尿病患者SHBG、NF-κBp65、Sfrp-5表达与病情存在密切关系,为靶向药物治疗妊娠期糖尿病提供新思路。

Objective:To study the correlation of the expressions of serum neutral hormone binding globulin(SHBG),human nuclear transcription factor p65(NF k Bp65)65,and crimp related protein 5(Sfrp 5)of pregnant women to their gestational diabetes mellitus(GDM)occurrence.Methods:100 women with GDM were selected in the observation group from February 2014 to February 2017,and 80 normal pregnant women were in the control group during the same period.The serum levels of SHBG,NF k Bp65 and Sfrp 5 of all included women were detected.Results:The blood glucose level of women in the observation group was significant higher than that of women in the control group at 30 minutes,1 hour and 2 hours after meal,and the insulin level was significant lower than that of women in the control group at 30 minutes and 2 hours after meal(P<0.05).The serum levels of SHBG and Sfrp 5 of women in the observation group were significant lower than those of women in the control group,but the level of NF k Bp65 was significant higher than that of women in the control group(P<0.05).The correlation analysis showed that levels of SHBG and Sfrp 5 were negatively correlated to the blood glucose and insulin levels,while level of NF k Bp65 was positively correlated to the blood glucose and insulin levels(P<0.05).Conclusion:The expression of SHBG,NF k Bp65 and Sfrp 5 of pregnant women is closely related to their occurrence of GDM,and it also provides new evidence for therapy of GDM by btargeted drug.