Wnt/β-catenin信号通路与特发性肺间质纤维化研究进展

Progress in Wnt/β-catenin signaling pathway and idiopathic pulmonary interstitial fibrosis

特发性肺纤维化是一种常见的肺部弥漫性纤维化疾病,发病机制不明,临床上缺乏有效治疗手段,病死率较高。Wnt/β-catenin信号通路参与细胞增殖、分化、运动及凋亡等过程,是细胞发育所必需及调节细胞行为和细胞间相互作用的一条高度保守的信号转导通路。两者密切相关,本文主要从Wnt/β-catenin信号通路中相关调控因子与IPF的关系及治疗靶点的研究方面做一综述。

Idiopathic pulmonary fibrosis is a common diffuse fibrotic disease in the lungs.The pathogenesis is unknown.There is no effective treatment in clinical practice and the mortality rate is high.Wnt/β-catenin signaling pathway is involved in cell proliferation,differentiation,movement and apoptosis,and is a highly conserved signal transduction pathway necessary for cell development and regulating cell behavior and cell-cell interaction.The two are closely related.This paper reviews the relationship between the related regulatory factors in Wnt/β-catenin signaling pathway and IPF and the research of therapeutic targets.